Patricia Coltri - USP

Patricia Coltri



Regulation of genetic expression in eukaryotes

My current research program is the investigation of splicing and its regulation. The great majority of eukaryotic RNA transcripts must be processed to generate mature messages. Splicing is the removal of intervening sequences, or introns, and ligation of exons into mature RNAs. These RNAs can be directed to translation or, in some cases, perform different roles in the cell.

Splicing is performed by specialized molecular machinery called the spliceosome. It is composed of RNAs and over 100 different proteins. Most of these are core components of the complex whereas some are regulatory factors. We use molecular and cell biology techniques to understand how this activity is modulated by different proteins and spliceosome components as well as by different sequences on transcripts.



Contact: coltri [at] usp [dot] br


Departamento de Biologia Celular e do Desenvolvimento - ICB-I
Av Prof Lineu Prestes, 1524, Cidade Universitária, São Paulo, SP, Brasil, 05508-000